Combining many interaction networks to predict gene function and analyze gene lists

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Combining many interaction networks to predict gene function and analyze gene lists

TitleCombining many interaction networks to predict gene function and analyze gene lists
Publication TypeJournal Article
Year of Publication2012
AuthorsMostafavi, S, Morris, Q
JournalPROTEOMICS
Volume12
Pagination1687-1696
Date PublishedMAY
Type of ArticleReview
ISSN1615-9853
KeywordsAlgorithm, Bioinformatics, Functional genomics, Molecular interaction, Web tool
AbstractIn this article, we review how interaction networks can be used alone or in combination in an automated fashion to provide insight into gene and protein function. We describe the concept of a gene-recommender system that can be applied to any large collection of interaction networks to make predictions about gene or protein function based on a query list of proteins that share a function of interest. We discuss these systems in general and focus on one specific system, GeneMANIA, that has unique features and uses different algorithms from the majority of other systems.
DOI10.1002/pmic.201100607