Exploring the ``Two-Hit hypothesis'' in NF2: Tests of two-hit and three-hit models of vestibular schwannoma development

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Exploring the ``Two-Hit hypothesis'' in NF2: Tests of two-hit and three-hit models of vestibular schwannoma development

TitleExploring the ``Two-Hit hypothesis'' in NF2: Tests of two-hit and three-hit models of vestibular schwannoma development
Publication TypeJournal Article
Year of Publication2003
AuthorsWoods, R, Friedman, JM, Evans, DGR, Baser, ME, Joe, H
JournalGenetic Epidemiology
Volume24
Pagination265-272
Date PublishedMAY
ISSN0741-0395
AbstractNeurofibromatosis 2 (NF2) is a genetic disease that occurs in approximately 1 in 40,000 live births. Almost all affected individuals develop bilateral tumors of Schwann cells that surround the vestibular nerves; these tumors are known as vestibular schwannomas (VS). Evidence from molecular genetic studies suggests that at least two mutations are involved in formation of VS in patients with NF2. Several authors proposed probabilistic models for this process in other tumors, and showed that such models are consistent with incidence data. We evaluated two different probabilistic models for a ``2-hit'' hypothesis for VS development in NF2 patients, and we present results from fitting these models to incidence data. Molecular evidence does not exclude the possibility that additional hits are necessary for the development of VS, and we also assessed a ``3-hit'' model for tumor formation. The ``3-hit'' model fits the data marginally better than one of the ``2-hit'' models and much better than the other ``2-hit'' model. Our findings suggest that more than two mutations may be necessary for VS development in NF2 patients. (C) 2003 Wiley-Liss, Inc.
DOI10.1002/gepi.10238