The Genetic Landscape of a Cell

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The Genetic Landscape of a Cell

TitleThe Genetic Landscape of a Cell
Publication TypeJournal Article
Year of Publication2010
AuthorsCostanzo, M, Baryshnikova, A, Bellay, J, Kim, Y, Spear, ED, Sevier, CS, Ding, H, Koh, JLY, Toufighi, K, Mostafavi, S, Prinz, J, Onge, RPSt., VanderSluis, B, Makhnevych, T, Vizeacoumar, FJ, Alizadeh, S, Bahr, S, Brost, RL, Chen, Y, Cokol, M, Deshpande, R, Li, Z, Lin, Z-Y, Liang, W, Marback, M, Paw, J, San Luis, B-J, Shuteriqi, E, Tong, AHin Yan, van Dyk, N, Wallace, IM, Whitney, JA, Weirauch, MT, Zhong, G, Zhu, H, Houry, WA, Brudno, M, Ragibizadeh, S, Papp, B, Pal, C, Roth, FP, Giaever, G, Nislow, C, Troyanskaya, OG, Bussey, H, Bader, GD, Gingras, A-C, Morris, QD, Kim, PM, Kaiser, CA, Myers, CL, Andrews, BJ, Boone, C
JournalSCIENCE
Volume327
Pagination425-431
Date PublishedJAN 22
Type of ArticleArticle
ISSN0036-8075
AbstractA genome-scale genetic interaction map was constructed by examining 5.4 million gene-gene pairs for synthetic genetic interactions, generating quantitative genetic interaction profiles for similar to 75% of all genes in the budding yeast, Saccharomyces cerevisiae. A network based on genetic interaction profiles reveals a functional map of the cell in which genes of similar biological processes cluster together in coherent subsets, and highly correlated profiles delineate specific pathways to define gene function. The global network identifies functional cross-connections between all bioprocesses, mapping a cellular wiring diagram of pleiotropy. Genetic interaction degree correlated with a number of different gene attributes, which may be informative about genetic network hubs in other organisms. We also demonstrate that extensive and unbiased mapping of the genetic landscape provides a key for interpretation of chemical-genetic interactions and drug target identification.
DOI10.1126/science.1180823