The Genotype-Tissue Expression (GTEx) project

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The Genotype-Tissue Expression (GTEx) project

TitleThe Genotype-Tissue Expression (GTEx) project
Publication TypeJournal Article
Year of Publication2013
AuthorsLonsdale, J, Thomas, J, Salvatore, M, Phillips, R, Lo, E, Shad, S, Hasz, R, Walters, G, Garcia, F, Young, N, Foster, B, Moser, M, Karasik, E, Gillard, B, Ramsey, K, Sullivan, S, Bridge, J, Magazine, H, Syron, J, Fleming, J, Siminoff, L, Traino, H, Mosavel, M, Barker, L, Jewell, S, Rohrer, D, Maxim, D, Filkins, D, Harbach, P, Cortadillo, E, Berghuis, B, Turner, L, Hudson, E, Feenstra, K, Sobin, L, Robb, J, Branton, P, Korzeniewski, G, Shive, C, Tabor, D, Qi, L, Groch, K, Nampally, S, Buia, S, Zimmerman, A, Smith, A, Burges, R, Robinson, K, Valentino, K, Bradbury, D, Cosentino, M, Diaz-Mayoral, N, Kennedy, M, Engel, T, Williams, P, Erickson, K, Ardlie, K, Winckler, W, Getz, G, DeLuca, D, MacArthur, D, Kellis, M, Thomson, A, Young, T, Gelfand, E, Donovan, M, Meng, Y, Grant, G, Mash, D, Marcus, Y, Basile, M, Liu, J, Zhu, J, Tu, Z, Cox, NJ, Nicolae, DL, Gamazon, ER, Im, HKyung, Konkashbaev, A, Pritchard, J, Stevens, M, Flutre, T, Wen, X, Dermitzakis, ET, Lappalainen, T, Guigo, R, Monlong, J, Sammeth, M, Koller, D, Battle, A, Mostafavi, S, McCarthy, M, Rivas, M, Maller, J, Rusyn, I, Nobel, A, Wright, F, Shabalin, A, Feolo, M, Sharopova, N, Sturcke, A, Paschal, J, Anderson, JM, Wilder, EL, Derr, LK, Green, ED, Struewing, JP, Temple, G, Volpi, S, Boyer, JT, Thomson, EJ, Guyer, MS, Ng, C, Abdallah, A, Colantuoni, D, Insel, TR, Koester, SE, A. Little, R, Bender, PK, Lehner, T, Yao, Y, Compton, CC, Vaught, JB, Sawyer, S, Lockhart, NC, Demchok, J, Moore, HF
JournalNATURE GENETICS
Volume45
Pagination580-585
Date PublishedJUN
Type of ArticleEditorial Material
ISSN1061-4036
AbstractGenome-wide association studies have identified thousands of loci for common diseases, but, for the majority of these, the mechanisms underlying disease susceptibility remain unknown. Most associated variants are not correlated with protein-coding changes, suggesting that polymorphisms in regulatory regions probably contribute to many disease phenotypes. Here we describe the Genotype-Tissue Expression (GTEx) project, which will establish a resource database and associated tissue bank for the scientific community to study the relationship between genetic variation and gene expression in human tissues.
DOI10.1038/ng.2653