HIV viral dynamic models with dropouts and missing covariates

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HIV viral dynamic models with dropouts and missing covariates

TitleHIV viral dynamic models with dropouts and missing covariates
Publication TypeJournal Article
Year of Publication2007
AuthorsWU, LANG
JournalStatistics in Medicine
Volume26
Pagination3342–3357
ISSN1097-0258
Keywordsapproximate method, Longitudinal data, missing data, Monte-Carlo EM, nonlinear mixed-effects model
AbstractIn recent years HIV viral dynamic models have received great attention in AIDS studies. Often, subjects in these studies may drop out for various reasons such as drug intolerance or drug resistance, and covariates may also contain missing data. Statistical analyses ignoring informative dropouts and missing covariates may lead to misleading results. We consider appropriate methods for HIV viral dynamic models with informative dropouts and missing covariates and evaluate these methods via simulations. A real data set is analysed, and the results show that the initial viral decay rate, which may reflect the efficacy of the anti-HIV treatment, may be over-estimated if dropout patients are ignored. We also find that the current or immediate previous viral load values may be most predictive for patients' dropout. These results may be important for HIV/AIDS studies. Copyright © 2007 John Wiley & Sons, Ltd.
URLhttp://onlinelibrary.wiley.com/doi/10.1002/sim.2816/abstract
DOI10.1002/sim.2816