A multiple imputation method for missing covariates in non-linear mixed-effects models with application to HIV dynamics

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A multiple imputation method for missing covariates in non-linear mixed-effects models with application to HIV dynamics

TitleA multiple imputation method for missing covariates in non-linear mixed-effects models with application to HIV dynamics
Publication TypeJournal Article
Year of Publication2001
AuthorsWu, H, WU, LANG
JournalStatistics in Medicine
Volume20
Pagination1755–1769
ISSN1097-0258
AbstractWe propose a three-step multiple imputation method, implemented by Gibbs sampler, for estimating parameters in non-linear mixed-effects models with missing covariates. Estimates obtained by the proposed multiple imputation method are compared to those obtained by the mean-value imputation method and the complete-case method through simulations. We find that the proposed multiple imputation method offers smaller biases and smaller mean-squared errors for the estimates of covariate coefficients compared to other two methods. We apply the three missing data methods to modelling HIV viral dynamics from an AIDS clinical trial. We believe that the results from the proposed multiple imputation method are more reliable than that from the other two commonly used methods. Copyright © 2001 John Wiley & Sons, Ltd.
URLhttp://onlinelibrary.wiley.com/doi/10.1002/sim.816/abstract
DOI10.1002/sim.816