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Penalized Casebase in Survival Analysis

Monday, August 29, 2022 - 11:00 to 11:30
Trevor Kwan, UBC Statistics MSc Student
Statistics Seminar

To Join Via Zoom: To join this seminar, please request Zoom connection details from headsec [at]

Abstract: A quantity of interest in clinical studies is the absolute risk of an event given a patient's covariate profile. In order for the Cox proportional hazard method to recover these absolute risk curves, the baseline hazard needs to be estimated separately, resulting in stepwise estimates in absolute risk that make the curves difficult to interpret. Casebase is an approach that transforms the data into a logistic regression, allowing for survival estimates that vary smoothly over time. We simulate data and compare the prediction performance of penalized casebase methods with penalized and unpenalized Cox methods. Casebase methods perform better in measures of concordance and time-dependent brier scores.