Abstract: Clinical trials are regarded as the most reliable way to evaluate the efficacy of new medical interventions. This practice has taken a prominent role in modern clinical research. However clinical experimentation on human subjects requires a careful balancing act between the benefit of the collective and the benefit of the individual. This talk is focused on statistical design and analysis of response adaptive Phase III clinical trials, which represent recent advancements in clinical trial methodology. The adaptive designs help balance the ethical issues and improve efficiency without undermining the validity and integrity of the clinical research. The talk is based on joint work with several graduate students.